UC Santa Cruz Neuroscience Cluster
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News 578 Publications 12 Members

Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo.

Zemmar, Ajmal Weinmann, Oliver Kellner, Yves Yu, Xinzhu Vicente, Raul Gullo, Miriam Kasper, Hansjörg Lussi, Karin Ristic, Zorica Luft, Andreas R ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical synaptic plasticity and motor learning in the uninjured adult rodent motor cortex. Nogo-A and its rece...

A unifying model of genome evolution under parsimony

Paten, Benedict Zerbino, Daniel R Hickey, Glenn Haussler, David

Published in BMC Bioinformatics

BackgroundParsimony and maximum likelihood methods of phylogenetic tree estimation and parsimony methods for genome rearrangements are central to the study of genome evolution yet to date they have largely been pursued in isolation.ResultsWe present a data structure called a history graph that offers a practical basis for the analysis of genome evo...

Role of emergent neural activity in visual map development

Ackman, James B Crair, Michael C

Published in Current Opinion in Neurobiology

The initial structural and functional development of visual circuits in reptiles, birds, and mammals happens independent of sensory experience. After eye opening, visual experience further refines and elaborates circuits that are critical for normal visual function. Innate genetic programs that code for gradients of molecules provide gross position...

Spatiotemporal dynamics of dendritic spines in the living brain

Chen, Chia-Chien Lu, Ju Yi Zuo

Published in Frontiers in Neuroanatomy

Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder canc...

Pinto-Leite, Rosário Carreira, Isabel Melo, Joana Ferreira, Susana Isabel Ribeiro, Ilda Ferreira, Jaqueline Filipe, Marco Bernardo, Carina Arantes-Rodrigues, Regina Oliveira, Paula ...

Published in Tumor Biology

Several genomic regions are frequently altered and associated with the type, stage and progression of urinary bladder cancer (UBC). We present the characterization of 5637, T24 and HT1376 UBC cell lines by karyotyping, fluorescence in situ hybridization (FISH), array comparative genomic hybridization (aCGH) and multiplex ligation-dependent probe am...

Deep Brain Stimulation for Tourette Syndrome: Target Selection

Viswanathan, Ashwin Jimenez-Shahed, Joohi Baizabal Carvallo, José Fidel Jankovic, Joseph

Published in Stereotactic and Functional Neurosurgery

Background/Aims: Tourette syndrome (TS) is a complex neurological disorder manifested chiefly by motor and phonic tics and a variety of behavioral comorbidities, including attention disorder, obsessive-compulsive disorder and impulse control problems. Surgical treatment is increasingly considered when tics become troublesome or even disabling or se...

Spatially patterned electrical stimulation to enhance resolution of retinal prostheses.

Jepson, Lauren H Hottowy, Paweł Mathieson, Keith Gunning, Deborah E Dąbrowski, Władysław Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Retinal prostheses electrically stimulate neurons to produce artificial vision in people blinded by photoreceptor degenerative diseases. The limited spatial resolution of current devices results in indiscriminate stimulation of interleaved cells of different types, precluding veridical reproduction of natural activity patterns in the retinal output...

Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Ri...

Mora, Ana M van Wendel de Joode, Berna Mergler, Donna Córdoba, Leonel Cano, Camilo Quesada, Rosario Smith, Donald R Menezes-Filho, José A Lundh, Thomas Lindh, Christian H ...

Published in Environmental science & technology

Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associa...

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in i...

Triplett, Jason W Wei, Wei Gonzalez, Cristina Sweeney, Neal T Huberman, Andrew D Feller, Marla B Feldheim, David A

Published in Neural Development

BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene. This functional specificity is derived from distinct RGC morphologies and selective synapse formation with other retinal cell types; yet, how these properties are established during develo...

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzhe...

Stutzbach, Lauren D Xie, Sharon X Naj, Adam C Albin, Roger Gilman, Sid Lee, Virginia M Y Trojanowski, John Q Devlin, Bernie Schellenberg, Gerard D

Published in Acta Neuropathologica Communications

BackgroundProgressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the end...

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