UC Santa Cruz Neuroscience Cluster
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News 578 Publications 12 Members

Comprehensive molecular profiling of lung adenocarcinoma. PDF available through Get Fulltext Research

Published in Nature

Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen gene...

High-fidelity reproduction of spatiotemporal visual signals for retinal prosthesis. PDF available through Get Fulltext Research

Jepson, Lauren H Hottowy, Pawel Weiner, Geoffrey A Dabrowski, Władysław Litke, Alan M Chichilnisky, E J

Published in Neuron

Natural vision relies on spatiotemporal patterns of electrical activity in the retina. We investigated the feasibility of veridically reproducing such patterns with epiretinal prostheses. Multielectrode recordings and visual and electrical stimulation were performed on populations of identified ganglion cells in isolated peripheral primate retina. ...

Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo.

Zemmar, Ajmal Weinmann, Oliver Kellner, Yves Yu, Xinzhu Vicente, Raul Gullo, Miriam Kasper, Hansjörg Lussi, Karin Ristic, Zorica Luft, Andreas R ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical synaptic plasticity and motor learning in the uninjured adult rodent motor cortex. Nogo-A and its rece...

A unifying model of genome evolution under parsimony PDF available through Get Fulltext Research

Paten, Benedict Zerbino, Daniel R Hickey, Glenn Haussler, David

Published in BMC Bioinformatics

BackgroundParsimony and maximum likelihood methods of phylogenetic tree estimation and parsimony methods for genome rearrangements are central to the study of genome evolution yet to date they have largely been pursued in isolation.ResultsWe present a data structure called a history graph that offers a practical basis for the analysis of genome evo...

The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzhe... PDF available through Get Fulltext Research

Stutzbach, Lauren D Xie, Sharon X Naj, Adam C Albin, Roger Gilman, Sid Lee, Virginia M Y Trojanowski, John Q Devlin, Bernie Schellenberg, Gerard D

Published in Acta Neuropathologica Communications

BackgroundProgressive supranuclear palsy (PSP) is a neurodegenerative disorder pathologically characterized by intracellular tangles of hyperphosphorylated tau protein distributed throughout the neocortex, basal ganglia, and brainstem. A genome-wide association study identified EIF2AK3 as a risk factor for PSP. EIF2AK3 encodes PERK, part of the end...

Role of emergent neural activity in visual map development

Ackman, James B Crair, Michael C

Published in Current Opinion in Neurobiology

The initial structural and functional development of visual circuits in reptiles, birds, and mammals happens independent of sensory experience. After eye opening, visual experience further refines and elaborates circuits that are critical for normal visual function. Innate genetic programs that code for gradients of molecules provide gross position...

Spatiotemporal dynamics of dendritic spines in the living brain

Chen, Chia-Chien Lu, Ju Zuo, Yi

Published in Frontiers in Neuroanatomy

Dendritic spines are ubiquitous postsynaptic sites of most excitatory synapses in the mammalian brain, and thus may serve as structural indicators of functional synapses. Recent works have suggested that neuronal coding of memories may be associated with rapid alterations in spine formation and elimination. Technological advances have enabled resea...

Adapter reagents for protein site specific dye labeling.

Thompson, Darren A Evans, Eric G B Kasza, Tomas Millhauser, Glenn L Dawson, Philip E

Published in Biopolymers

Chemoselective protein labeling remains a significant challenge in chemical biology. Although many selective labeling chemistries have been reported, the practicalities of matching the reaction with appropriately functionalized proteins and labeling reagents is often a challenge. For example, we encountered the challenge of site specifically labeli...

Genomic characterization of three urinary bladder cancer cell lines: understanding genomic types of urinary bladder canc...

Pinto-Leite, Rosário Carreira, Isabel Melo, Joana Ferreira, Susana Isabel Ribeiro, Ilda Ferreira, Jaqueline Filipe, Marco Bernardo, Carina Arantes-Rodrigues, Regina Oliveira, Paula ...

Published in Tumor Biology

Several genomic regions are frequently altered and associated with the type, stage and progression of urinary bladder cancer (UBC). We present the characterization of 5637, T24 and HT1376 UBC cell lines by karyotyping, fluorescence in situ hybridization (FISH), array comparative genomic hybridization (aCGH) and multiplex ligation-dependent probe am...

Deep Brain Stimulation for Tourette Syndrome: Target Selection PDF available through Get Fulltext Research

Viswanathan, Ashwin Jimenez-Shahed, Joohi Baizabal Carvallo, José Fidel Jankovic, Joseph

Published in Stereotactic and Functional Neurosurgery

Background/Aims: Tourette syndrome (TS) is a complex neurological disorder manifested chiefly by motor and phonic tics and a variety of behavioral comorbidities, including attention disorder, obsessive-compulsive disorder and impulse control problems. Surgical treatment is increasingly considered when tics become troublesome or even disabling or se...

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