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News 578 Publications 12 Members

Metal fractionation in soils and assessment of environmental contamination in Vallecamonica, Italy

Borgese, L. Federici, S. Zacco, A. Gianoncelli, A. Rizzo, L. Smith, D. R. Donna, F. Lucchini, R. Depero, L. E. Bontempi, E. ...

Published in Environmental Science and Pollution Research

Metal contamination was investigated in soils of the Vallecamonica, an area in the northern part of the Brescia province (Italy), where ferroalloy industries were active for a century until 2001. The extent in which emissions from ferroalloy plants affected metal concentration in soils is not known in this area. In this study, the geogenic and/or a...

PirB regulates a structural substrate for cortical plasticity

Djurisic, M. Vidal, G. S. Mann, M. Aharon, A. Kim, T. Ferrao Santos, A. Yi Zuo Hubener, M. Shatz, C. J.

Published in Proceedings of the National Academy of Sciences

Mechanistic study on the solution-phase n-doping of 1,3-dimethyl-2-aryl-2,3-dihydro-1H-benzoimidazole derivatives.

Naab, Benjamin D Guo, Song Olthof, Selina Evans, Eric G B Wei, Peng Millhauser, Glenn L Kahn, Antoine Barlow, Stephen Marder, Seth R Bao, Zhenan ...

Published in Journal of the American Chemical Society

The discovery of air-stable n-dopants for organic semiconductor materials has been hindered by the necessity of high-energy HOMOs and the air sensitivity of compounds that satisfy this requirement. One strategy for circumventing this problem is to utilize stable precursor molecules that form the active doping complex in situ during the doping proce...

Integrative annotation of variants from 1092 humans: application to cancer genomics.

Khurana, Ekta Fu, Yao Colonna, Vincenza Mu, Xinmeng Jasmine Kang, Hyun Min Lappalainen, Tuuli Sboner, Andrea Lochovsky, Lucas Chen, Jieming Harmanci, Arif ...

Published in Science (New York, N.Y.)

Interpreting variants, especially noncoding ones, in the increasing number of personal genomes is challenging. We used patterns of polymorphisms in functionally annotated regions in 1092 humans to identify deleterious variants; then we experimentally validated candidates. We analyzed both coding and noncoding regions, with the former corroborating ...

Determinants of manganese in prenatal dentin of shed teeth from CHAMACOS children living in an agricultural community.

Gunier, Robert B Bradman, Asa Jerrett, Michael Smith, Donald R Harley, Kim G Austin, Christine Vedar, Michelle Arora, Manish Eskenazi, Brenda

Published in Environmental science & technology

Manganese (Mn) is an essential nutrient, but overexposure can be neurotoxic. Over 800 000 kg of Mn-containing fungicides are applied each year in California. Manganese levels in teeth are a promising biomarker of perinatal exposure. Participants in our analysis included 207 children enrolled in the Center for the Health Assessment of Mothers and Ch...

The Cancer Genome Atlas Pan-Cancer analysis project.

Weinstein, John N Collisson, Eric A Mills, Gordon B Shaw, Kenna R Mills Ozenberger, Brad A Ellrott, Kyle Shmulevich, Ilya Sander, Chris Stuart, Joshua M

Published in Nature genetics

The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pa...

Molecular and functional analysis of human β-defensin 3 action at melanocortin receptors.

Nix, Matthew A Kaelin, Christopher B Ta, Tina Weis, Allison Morton, Gregory J Barsh, Gregory S Millhauser, Glenn L

Published in Chemistry & biology

The β-defensins are a class of small, cationic proteins first recognized as antimicrobial components of the innate and adaptive immune system. More recently, one of the major β-defensins produced in skin, β-defensin 3, has been discovered to function as a melanocortin receptor ligand in vivo and in vitro, but its biophysical and pharmacological bas...

Integrated genomic characterization of endometrial carcinoma

Kandoth, Cyriac Schultz, Nikolaus Cherniack, Andrew D. Akbani, Rehan Liu, Yuexin Shen, Hui Gordon Robertson, A. Pashtan, Itai Shen, Ronglai Benz, Christopher C. ...

Published in Nature

This paper from The Cancer Genome Atlas Research Network presents an in-depth genome-wide analysis of endometrial (uterine) carcinomas from more than 350 patients. Based on a series of genomic features including newly identified hotspot mutations in the DNA polymerase gene POLE, and novel mutations in the ARID5B DNA-binding protein, the authors pro...

Restoration of retinal structure and function after selective photocoagulation.

Sher, Alexander Jones, Bryan W Huie, Philip Paulus, Yannis M Lavinsky, Daniel Leung, Loh-Shan S Nomoto, Hiroyuki Beier, Corinne Marc, Robert E Palanker, Daniel ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina after injury or disease was thought to be limited to restructuring resulting in abnormal retinal anatomy and function. Here we report that neurons in the mammalian retina change their connectivit...

Retrotransposition of gene transcripts leads to structural variation in mammalian genomes

Ewing, Adam D Ballinger, Tracy J Earl, Dent Harris, Christopher C Ding, Li Wilson, Richard K Haussler, David

Published in Genome Biology

BackgroundRetroposed processed gene transcripts are an important source of material for new gene formation on evolutionary timescales. Most prior work on gene retrocopy discovery compared copies in reference genome assemblies to their source genes. Here, we explore gene retrocopy insertion polymorphisms (GRIPs) that are present in the germlines of ...

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