UC Santa Cruz Neuroscience Cluster
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News 578 Publications 12 Members

Tbr2 is required to generate a neural circuit mediating the pupillary light reflex.

Sweeney, Neal T Tierney, Hannah Feldheim, David A

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

There are ∼20 types of retinal ganglion cells (RGCs) in mice, each of which has distinct molecular, morphological, and physiological characteristics. Each RGC type sends axon projections to specific brain areas that execute light-dependent behaviors. Here, we show that the T-box transcription factor Tbr2 is required for the development of several R...

Spatially patterned electrical stimulation to enhance resolution of retinal prostheses.

Jepson, Lauren H Hottowy, Paweł Mathieson, Keith Gunning, Deborah E Dąbrowski, Władysław Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Retinal prostheses electrically stimulate neurons to produce artificial vision in people blinded by photoreceptor degenerative diseases. The limited spatial resolution of current devices results in indiscriminate stimulation of interleaved cells of different types, precluding veridical reproduction of natural activity patterns in the retinal output...

Blood and hair manganese concentrations in pregnant women from the infants' environmental health study (ISA) in Costa Ri...

Mora, Ana M van Wendel de Joode, Berna Mergler, Donna Córdoba, Leonel Cano, Camilo Quesada, Rosario Smith, Donald R Menezes-Filho, José A Lundh, Thomas Lindh, Christian H ...

Published in Environmental science & technology

Manganese (Mn), an essential nutrient, is a neurotoxicant at high concentrations. We measured Mn concentrations in repeated blood and hair samples collected from 449 pregnant women living near banana plantations with extensive aerial spraying of Mn-containing fungicide mancozeb in Costa Rica, and examined environmental and lifestyle factors associa...

A polyaxonal amacrine cell population in the primate retina.

Greschner, Martin Field, Greg D Li, Peter H Schiff, Max L Gauthier, Jeffrey L Ahn, Daniel Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Amacrine cells are the most diverse and least understood cell class in the retina. Polyaxonal amacrine cells (PACs) are a unique subset identified by multiple long axonal processes. To explore their functional properties, populations of PACs were identified by their distinctive radially propagating spikes in large-scale high-density multielectrode ...

Dendritic and axonal targeting patterns of a genetically-specified class of retinal ganglion cells that participate in i... PDF available through Get Fulltext Research

Triplett, Jason W Wei, Wei Gonzalez, Cristina Sweeney, Neal T Huberman, Andrew D Feller, Marla B Feldheim, David A

Published in Neural Development

BackgroundThere are numerous functional types of retinal ganglion cells (RGCs), each participating in circuits that encode a specific aspect of the visual scene. This functional specificity is derived from distinct RGC morphologies and selective synapse formation with other retinal cell types; yet, how these properties are established during develo...

Retinal representation of the elementary visual signal. PDF available through Get Fulltext Research

Li, Peter H Field, Greg D Greschner, Martin Ahn, Daniel Gunning, Deborah E Mathieson, Keith Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in Neuron

The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong respo...

Current status and new features of the Consensus Coding Sequence database.

Farrell, Catherine M O'Leary, Nuala A Harte, Rachel A Loveland, Jane E Wilming, Laurens G Wallin, Craig Diekhans, Mark Barrell, Daniel Searle, Stephen M J Aken, Bronwen ...

Published in Nucleic acids research

The Consensus Coding Sequence (CCDS) project (http://www.ncbi.nlm.nih.gov/CCDS/) is a collaborative effort to maintain a dataset of protein-coding regions that are identically annotated on the human and mouse reference genome assemblies by the National Center for Biotechnology Information (NCBI) and Ensembl genome annotation pipelines. Identical an...

Metal fractionation in soils and assessment of environmental contamination in Vallecamonica, Italy

Borgese, L. Federici, S. Zacco, A. Gianoncelli, A. Rizzo, L. Smith, D. R. Donna, F. Lucchini, R. Depero, L. E. Bontempi, E. ...

Published in Environmental Science and Pollution Research

Metal contamination was investigated in soils of the Vallecamonica, an area in the northern part of the Brescia province (Italy), where ferroalloy industries were active for a century until 2001. The extent in which emissions from ferroalloy plants affected metal concentration in soils is not known in this area. In this study, the geogenic and/or a...

PirB regulates a structural substrate for cortical plasticity

Djurisic, M. Vidal, G. S. Mann, M. Aharon, A. Kim, T. Ferrao Santos, A. Yi Zuo Hubener, M. Shatz, C. J.

Published in Proceedings of the National Academy of Sciences

The somatic genomic landscape of glioblastoma.

Brennan, Cameron W Verhaak, Roel G W McKenna, Aaron Campos, Benito Noushmehr, Houtan Salama, Sofie R Zheng, Siyuan Chakravarty, Debyani Sanborn, J Zachary Berman, Samuel H ...

Published in Cell

We describe the landscape of somatic genomic alterations based on multidimensional and comprehensive characterization of more than 500 glioblastoma tumors (GBMs). We identify several novel mutated genes as well as complex rearrangements of signature receptors, including EGFR and PDGFRA. TERT promoter mutations are shown to correlate with elevated m...

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