UC Santa Cruz Neuroscience Cluster
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News 578 Publications 12 Members

Editing modifies the GABA(A) receptor subunit alpha3.

Ohlson, J Pedersen, Js David Haussler Ohman, M

Published in RNA

Adenosine to inosine (A-to-I) pre-mRNA editing by the ADAR enzyme family has the potential to increase the variety of the proteome. This editing by adenosine deamination is essential in mammals for a functional brain. To detect novel substrates for A-to-I editing we have used an experimental method to find selectively edited sites and combined it w...

Physiological consequences of the complete loss of phosphoryl-transfer proteins HPr and FPr of the phosphoenolpyruvate:s...

David Feldheim Chin, Am Nierva, Ct Feucht, Bu Cao, Yw Xu, Yf Sutrina, Sl Saier Mh, Jr

Published in Journal of Bacteriology

Mutants of Salmonella typhimurium defective in the proteins of the fructose operon [fruB(MH)KA], the fructose repressor (fruR), the energy-coupling enzymes of the phosphoenolpyruvate:sugar phosphotransferase system (PTS) (ptsH and ptsI), and the proteins of cyclic AMP action (cya and crp) were analyzed for their effects on cellular physiological pr...

Distance-dependent Fluorescence Quenching and Binding of CdSe Quantum Dots by Functionalized Nitroxide Radicals.

Tansakul, C Lilie, E Walter, Ed Rivera F, 3rd Wolcott, A Zhang, Jz Glenn Millhauser Braslau, R

Published in The Journal of Physical Chemistry C

Quantum dot (QD) fluorescence is effectively quenched at low concentration by nitroxides bearing amine or carboxylic acid ligands. The association constants and fluorescence quenching of CdSe QDs with these derivatized nitroxides have been examined using electron paramagnetic resonance (EPR) and fluorescence spectroscopy. The EPR spectra in the non...

Testing the conformational hypothesis of passive membrane permeability using synthetic cyclic peptide diastereomers.

Rezai, T Yu, B Glenn Millhauser Jacobson, Mp Lokey, Rs

Published in Journal of the American Chemical Society

Little is known about the effect of conformation on passive membrane diffusion rates in small molecules. Evidence suggests that intramolecular hydrogen bonding may play a role by reducing the energetic cost of desolvating hydrogen bond donors, especially amide N-H groups. We set out to test this hypothesis by investigating the passive membrane diff...

Electron interferometry at a metal-semiconductor interface.

Joel Kubby Greene, Wj

Published in Physical Review Letters

Rheology of milk foams produced by steam injection.

Jimenez-Junca, Ca Gumy, Jc Alexander Sher Niranjan, K

Published in Journal of Food Science

Reptation theory of ion channel gating.

Glenn Millhauser

Published in Biophysical Journal

Reptation theory is a highly successful approach for describing polymer dynamics in entangled systems. In turn, this molecular process is the basis of viscoelasticity. We apply a modified version of reptation dynamics to develop an actual physical model of ion channel gating. We show that at times longer than microseconds these dynamics predict an ...

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