Stellato, Francesco Spevacek, Ann Proux, Olivier Minicozzi, Velia Millhauser, Glenn Morante, Silvia
Published in
European Biophysics Journal
In this work we present and analyse XAS measurements carried out on various portions of Prion-protein tetra-octa-repeat peptides in complexes with Cu(II) ions, both in the presence and in the absence of Zn(II). Because of the ability of the XAS technique to provide detailed local structural information, we are able to demonstrate that Zn acts by di...
Stellato, Francesco Minicozzi, Velia Millhauser, Glenn L. Pascucci, Marco Proux, Olivier Rossi, Giancarlo C. Spevacek, Ann Morante, Silvia
Published in
European Biophysics Journal
In this paper we report a systematic XAS study of a set of samples in which Cu(II) was progressively added to complexes in which Zn(II) was bound to the tetra-octarepeat portion of the prion protein. This work extends previous EPR and XAS analysis in which, in contrast, the effect of adding Zn(II) to Cu(II)–tetra-octarepeat complexes was investigat...
