Accelerated Experience-Dependent Pruning of Cortical Synapses in Ephrin-A2 Knockout Mice
Published in Neuron
Accelerated Experience-Dependent Pruning of Cortical Synapses in Ephrin-A2 Knockout Mice
Spatial-temporal patterns of retinal waves underlying activity-dependent refinement of retinofugal projections.
Published in Neuron
During development, retinal axons project coarsely within their visual targets before refining to form organized synaptic connections. Spontaneous retinal activity, in the form of acetylcholine-driven retinal waves, is proposed to be necessary for establishing these projection patterns. In particular, both axonal terminations of retinal ganglion ce...
Ephrin-as guide the formation of functional maps in the visual cortex.
Published in Neuron
Ephrin-As and their receptors, EphAs, are expressed in the developing cortex where they may act to organize thalamic inputs. Here, we map the visual cortex (V1) in mice deficient for ephrin-A2, -A3, and -A5 functionally, using intrinsic signal optical imaging and microelectrode recording, and structurally, by anatomical tracing of thalamocortical p...
Cadherin-6 mediates axon-target matching in a non-image-forming visual circuit.
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Published in Neuron
Neural circuits consist of highly precise connections among specific types of neurons that serve a common functional goal. How neurons distinguish among different synaptic targets to form functionally precise circuits remains largely unknown. Here, we show that during development, the adhesion molecule cadherin-6 (Cdh6) is expressed by a subset of ...
High-fidelity reproduction of spatiotemporal visual signals for retinal prosthesis.
Published in Neuron
Natural vision relies on spatiotemporal patterns of electrical activity in the retina. We investigated the feasibility of veridically reproducing such patterns with epiretinal prostheses. Multielectrode recordings and visual and electrical stimulation were performed on populations of identified ganglion cells in isolated peripheral primate retina. ...
Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers.
Published in Neuron
Motor axons form topographic maps on muscles: rostral motor pools innervate rostral muscles, and rostral portions of motor pools innervate rostral fibers within their targets. Here, we implicate A subfamily ephrins in this topographic mapping. First, developing muscles express all five of the ephrin-A genes. Second, rostrally and caudally derived m...
Development of Long-Term Dendritic Spine Stability in Diverse Regions of Cerebral Cortex
Published in Neuron
Selective disruption of one Cartesian axis of cortical maps and receptive fields by deficiency in ephrin-As and structur...
Published in Neuron
The topographic representation of visual space is preserved from retina to thalamus to cortex. We have previously shown that precise mapping of thalamocortical projections requires both molecular cues and structured retinal activity. To probe the interaction between these two mechanisms, we studied mice deficient in both ephrin-As and retinal waves...
Visual circuit development requires patterned activity mediated by retinal acetylcholine receptors.
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Published in Neuron
The elaboration of nascent synaptic connections into highly ordered neural circuits is an integral feature of the developing vertebrate nervous system. In sensory systems, patterned spontaneous activity before the onset of sensation is thought to influence this process, but this conclusion remains controversial, largely due to the inherent difficul...
Retinal representation of the elementary visual signal.
Published in Neuron
The propagation of visual signals from individual cone photoreceptors through parallel neural circuits was examined in the primate retina. Targeted stimulation of individual cones was combined with simultaneous recording from multiple retinal ganglion cells of identified types. The visual signal initiated by an individual cone produced strong respo...
