Cang, Jianhua Wang, Lupeng Stryker, Michael P Feldheim, David A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The orderly projections from retina to superior colliculus (SC) preserve a continuous retinotopic representation of the visual world. The development of retinocollicular maps depend on a combination of molecular guidance cues and patterned neural activity. Here, we characterize the functional retinocollicular maps in mice lacking the guidance molec...
Grunditz, Asa Holbro, Niklaus Tian, Lei Zuo, Yi Oertner, Thomas G
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Dendritic spines have been proposed to function as electrical compartments for the active processing of local synaptic signals. However, estimates of the resistance between the spine head and the parent dendrite suggest that compartmentalization is not tight enough to electrically decouple the synapse. Here we show in acute hippocampal slices that ...
Sher, Alexander Jones, Bryan W Huie, Philip Paulus, Yannis M Lavinsky, Daniel Leung, Loh-Shan S Nomoto, Hiroyuki Beier, Corinne Marc, Robert E Palanker, Daniel
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina after injury or disease was thought to be limited to restructuring resulting in abnormal retinal anatomy and function. Here we report that neurons in the mammalian retina change their connectivit...
Shanks, James A Ito, Shinya Schaevitz, Laura Yamada, Jena Chen, Bin Litke, Alan Feldheim, David A
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The dorsal lateral geniculate nucleus (dLGN) is a sensory thalamic relay area that receives feedforward inputs from retinal ganglion cells (RGCs) in the retina, and feed back inputs from layer 6 neurons in the visual cortex. In this study we examined genetically manipulated mice that develop without a cortex or without cortical layer 6 axonal proje...
Shlens, Jonathon Field, Greg D Gauthier, Jeffrey L Greschner, Martin Sher, Alexander Litke, Alan M Chichilnisky, E J
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Synchronized firing among neurons has been proposed to constitute an elementary aspect of the neural code in sensory and motor systems. However, it remains unclear how synchronized firing affects the large-scale patterns of activity and redundancy of visual signals in a complete population of neurons. We recorded simultaneously from hundreds of ret...
Ackman, James B Aniksztejn, Laurent Crépel, Valérie Becq, Hélène Pellegrino, Christophe Cardoso, Carlos Ben-Ari, Yehezkel Represa, Alfonso
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the underlying mechanisms are not known. DCX(-/-) mice have been generated to investigate this issue. However, they display no neocortical abnormality, lessening their impact on the field. In contrast, ...
Zemmar, Ajmal Weinmann, Oliver Kellner, Yves Yu, Xinzhu Vicente, Raul Gullo, Miriam Kasper, Hansjörg Lussi, Karin Ristic, Zorica Luft, Andreas R
...
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical synaptic plasticity and motor learning in the uninjured adult rodent motor cortex. Nogo-A and its rece...
Zuo, Yi Lubischer, Jane L Kang, Hyuno Tian, Le Mikesh, Michelle Marks, Alexander Scofield, Virginia L Maika, Shan Newman, Craig Krieg, Paul
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
To enable vital observation of glia at the neuromuscular junction, transgenic mice were generated that express proteins of the green fluorescent protein family under control of transcriptional regulatory sequences of the human S100B gene. Terminal Schwann cells were imaged repetitively in living animals of one of the transgenic lines to show that, ...
Allène, Camille Cattani, Adriano Ackman, James B Bonifazi, Paolo Aniksztejn, Laurent Ben-Ari, Yehezkel Cossart, Rosa
Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Developing cortical networks generate a variety of coherent activity patterns that participate in circuit refinement. Early network oscillations (ENOs) are the dominant network pattern in the rodent neocortex for a short period after birth. These large-scale calcium waves were shown to be largely driven by glutamatergic synapses albeit GABA is a ma...
Tang, Aonan Jackson, David Hobbs, Jon Chen, Wei Smith, Jodi L Patel, Hema Prieto, Anita Petrusca, Dumitru Grivich, Matthew I Sher, Alexander
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Published in
The Journal of neuroscience : the official journal of the Society for Neuroscience
Multineuron firing patterns are often observed, yet are predicted to be rare by models that assume independent firing. To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and pairwise interactions as parameters (Schneidman et al., 2006; Shlens et al., 2006...
