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Roles of ephrin-as and structured activity in the development of functional maps in the superior colliculus.

Cang, Jianhua Wang, Lupeng Stryker, Michael P Feldheim, David A

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The orderly projections from retina to superior colliculus (SC) preserve a continuous retinotopic representation of the visual world. The development of retinocollicular maps depend on a combination of molecular guidance cues and patterned neural activity. Here, we characterize the functional retinocollicular maps in mice lacking the guidance molec...

Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization.

Grunditz, Asa Holbro, Niklaus Tian, Lei Zuo, Yi Oertner, Thomas G

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Dendritic spines have been proposed to function as electrical compartments for the active processing of local synaptic signals. However, estimates of the resistance between the spine head and the parent dendrite suggest that compartmentalization is not tight enough to electrically decouple the synapse. Here we show in acute hippocampal slices that ...

Restoration of retinal structure and function after selective photocoagulation.

Sher, Alexander Jones, Bryan W Huie, Philip Paulus, Yannis M Lavinsky, Daniel Leung, Loh-Shan S Nomoto, Hiroyuki Beier, Corinne Marc, Robert E Palanker, Daniel ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

CNS neurons change their connectivity to accommodate a changing environment, form memories, or respond to injury. Plasticity in the adult mammalian retina after injury or disease was thought to be limited to restructuring resulting in abnormal retinal anatomy and function. Here we report that neurons in the mammalian retina change their connectivit...

Corticothalamic Axons Are Essential for Retinal Ganglion Cell Axon Targeting to the Mouse Dorsal Lateral Geniculate Nucl...

Shanks, James A Ito, Shinya Schaevitz, Laura Yamada, Jena Chen, Bin Litke, Alan Feldheim, David A

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The dorsal lateral geniculate nucleus (dLGN) is a sensory thalamic relay area that receives feedforward inputs from retinal ganglion cells (RGCs) in the retina, and feed back inputs from layer 6 neurons in the visual cortex. In this study we examined genetically manipulated mice that develop without a cortex or without cortical layer 6 axonal proje...

The structure of large-scale synchronized firing in primate retina.

Shlens, Jonathon Field, Greg D Gauthier, Jeffrey L Greschner, Martin Sher, Alexander Litke, Alan M Chichilnisky, E J

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Synchronized firing among neurons has been proposed to constitute an elementary aspect of the neural code in sensory and motor systems. However, it remains unclear how synchronized firing affects the large-scale patterns of activity and redundancy of visual signals in a complete population of neurons. We recorded simultaneously from hundreds of ret...

Abnormal network activity in a targeted genetic model of human double cortex.

Ackman, James B Aniksztejn, Laurent Crépel, Valérie Becq, Hélène Pellegrino, Christophe Cardoso, Carlos Ben-Ari, Yehezkel Represa, Alfonso

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

In human patients, cortical dysplasia produced by Doublecortin (DCX) mutations lead to mental retardation and intractable infantile epilepsies, but the underlying mechanisms are not known. DCX(-/-) mice have been generated to investigate this issue. However, they display no neocortical abnormality, lessening their impact on the field. In contrast, ...

Neutralization of Nogo-A enhances synaptic plasticity in the rodent motor cortex and improves motor learning in vivo.

Zemmar, Ajmal Weinmann, Oliver Kellner, Yves Yu, Xinzhu Vicente, Raul Gullo, Miriam Kasper, Hansjörg Lussi, Karin Ristic, Zorica Luft, Andreas R ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

The membrane protein Nogo-A is known as an inhibitor of axonal outgrowth and regeneration in the CNS. However, its physiological functions in the normal adult CNS remain incompletely understood. Here, we investigated the role of Nogo-A in cortical synaptic plasticity and motor learning in the uninjured adult rodent motor cortex. Nogo-A and its rece...

Sequential generation of two distinct synapse-driven network patterns in developing neocortex.

Allène, Camille Cattani, Adriano Ackman, James B Bonifazi, Paolo Aniksztejn, Laurent Ben-Ari, Yehezkel Cossart, Rosa

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Developing cortical networks generate a variety of coherent activity patterns that participate in circuit refinement. Early network oscillations (ENOs) are the dominant network pattern in the rodent neocortex for a short period after birth. These large-scale calcium waves were shown to be largely driven by glutamatergic synapses albeit GABA is a ma...

Fluorescent proteins expressed in mouse transgenic lines mark subsets of glia, neurons, macrophages, and dendritic cells...

Zuo, Yi Lubischer, Jane L Kang, Hyuno Tian, Le Mikesh, Michelle Marks, Alexander Scofield, Virginia L Maika, Shan Newman, Craig Krieg, Paul ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

To enable vital observation of glia at the neuromuscular junction, transgenic mice were generated that express proteins of the green fluorescent protein family under control of transcriptional regulatory sequences of the human S100B gene. Terminal Schwann cells were imaged repetitively in living animals of one of the transgenic lines to show that, ...

A maximum entropy model applied to spatial and temporal correlations from cortical networks in vitro.

Tang, Aonan Jackson, David Hobbs, Jon Chen, Wei Smith, Jodi L Patel, Hema Prieto, Anita Petrusca, Dumitru Grivich, Matthew I Sher, Alexander ...

Published in The Journal of neuroscience : the official journal of the Society for Neuroscience

Multineuron firing patterns are often observed, yet are predicted to be rare by models that assume independent firing. To explain these correlated network states, two groups recently applied a second-order maximum entropy model that used only observed firing rates and pairwise interactions as parameters (Schneidman et al., 2006; Shlens et al., 2006...

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